Finite Absorption Time (F.A.T.) publications

1. On an Unphysical Hypothesis of Bateman Equation and its Implications for Pharmacokinetics
   Panos Macheras
   Pharm. Res. 36, 94 (2019)
   [DOI: 10.1007/s11095-019-2633-4] [PDF]
2. Revising Pharmacokinetics of Oral Drug Absorption: I Models Based on Biopharmaceutical/Physiological and Finite Absorption Time Concepts
   Panos Macheras, Pavlos Chryssafidis
   Pharm. Res. 37, 187 (2020)
   [DOI: 10.1007/s11095-020-02894-w] [PDF]
   Correction to: Revising Pharmacokinetics of Oral Drug Absorption: I Models Based on Biopharmaceutical/Physiological and Finite Absorption Time Concepts
   Panos Macheras, Pavlos Chryssafidis
   Pharm. Res. 37, 206 (2020)
   [DOI: 10.1007/s11095-020-02935-4] [PDF]
3. Revising Pharmacokinetics of Oral Drug Absorption: II Bioavailability-Bioequivalence Considerations
   Pavlos Chryssafidis, Athanasios A. Tsekouras, Panos Macheras
   Pharm. Res. 38, 1345-1356 (2021)
   [DOI: 10.1007/s11095-021-03078-w] [PDF]
   Correction to: Revising Pharmacokinetics of Oral Drug Absorption: II Bioavailability-Bioequivalence Considerations
   Pavlos Chryssafidis, Athanasios A. Tsekouras, Panos Macheras
   Pharm. Res. 38, 1633 (2021)
   [DOI: 10.1007/s11095-021-03101-0] [PDF]
4. Re-examining digoxin bioavailability after half a century: Time for changes in the bioavailability concepts
   Athanasios A. Tsekouras, Panos Macheras
   Pharm. Res. 38, 1635-1638 (2021)
   [DOI: 10.1007/s11095-021-03121-w] [PDF]
   Correction to: Re-examining digoxin bioavailability after half a century: Time for changes in the bioavailability concepts
   Athanasios A. Tsekouras, Panos Macheras
   Pharm. Res. 38, 2185 (2021)
   [DOI: 10.1007/s11095-021-03148-z] [PDF]
5. Re-writing oral pharmacokinetics using physiologically based finite time pharmacokinetic (PBFTPK) models
   P. Chryssafidis, A. A. Tsekouras, P. Macheras
   Pharm. Res. 39, 691-701 (2022)
   [DOI: 10.1007/s11095-022-03230-0] [PDF]
6. Columbus' egg: Oral drugs are absorbed in finite time
   P. Macheras, A. A. Tsekouras
   Eur. J. Pharm. Sci. 176, 106265 (2022)
   [DOI: 10.1016/j.ejps.2022.106265] [PDF] [Supplementary Information]
7. Physiologically based pharmacokinetic models under the prism of the finite absorption time concept
   Di Wu, Athanasios A. Tsekouras, Panos Macheras, Filippos Kesisoglou
   Pharm. Res. 40, 419-429 (2023)
   [DOI: 10.1007/s11095-022-03357-0] [PDF]
8. The Finite Absorption Time (FAT) Concept en route to PBPK modeling and pharmacometrics
   Athanasios A. Tsekouras, Panos Macheras
   J. Pharmacokin. Pharmacodyn. 50, 5-10 (2023)
   [DOI: 10.1007/s10928-022-09832-w] [PDF]
9. Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept
   Athanasios A. Tsekouras, Panos Macheras
   Eur. J. Drug Metabol. Pharmacokin. 48, 455-462 (2023)
   [DOI: 10.1007/s13318-023-00831-x] [PDF]
10. Revamping Biopharmaceutics-Pharmacokinetics with Scientific and Regulatory Implications for Oral Drug Absorption
    N. Alimpertis, A. A. Tsekouras, P. Macheras
    Pharm. Res. 40, (2023)
    [DOI: 10.1007/s11095-023-03578-x] [PDF] [Supplementary Information]
11. IVIVC revised
    N. Alimpertis, A. Simitopoulos, A. A. Tsekouras, P. Macheras
    Pharm. Res. 41, 235-246 (2024)
    [DOI: 10.1007/s11095-024-03653-x] [PDF]
12. Coupling Drug Dissolution with BCS
    A. Simitopoulos, A. A. Tsekouras, P. Macheras
    Pharm. Res. 41, 481-491 (2024)
    [DOI: 10.1007/s11095-024-03661-x] [PDF]
13. Application of the Finite Absorption Time (F.A.T.) Concept in the Assessment of Bioequivalence
    A. A. Tsekouras, P. Macheras
    Pharm. Res. 41, 1413-1425 (2024)
    [DOI: 10.1007/s11095-024-03727-w] [PDF]
14. FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes
    E. Toulitsis, A. A. Tsekouras, P. Macheras
    Pharmaceutics 16, 1435 (2024)
    [DOI: 10.3390/pharmaceutics16111435] [PDF] [Supplementary Information]
15. The Finite Absorption Time Concept Guiding Model Informed Drug & Generics Development in Clinical Pharmacology
    P. Macheras, A. A. Tsekouras, S. Sánchez-Herrero, K. Kosmidis
    Pharm. Res. 42, (2025)
    [DOI: 10.1007/s11095-025-03878-4] [PDF]