Platinum and palladium catalysed carbonylations
The planned talk is focused on the application of carbon monoxide in various transition metal catalysed reactions (carbonylations). The selective ‘build-in’ of a ‘C1- unit’ into model compounds or a more complicated skeleton of practical importance, is still an extremely important undertaking and a formidable challenge to a synthetic chemist. The activation of carbon monoxide by transition metal complexes provides an efficient way to the synthesis of building blocks (optically active building blocks) and compounds of biological (pharmaceutical) importance. In order to get a deeper insight into carbonylation reactions, some mechanistic aspects of the reactions will be also discussed.
The following topics will be addressed.
i) Hydroformylation of (prochiral) olefins in the presence of achiral and optically active platinum complexes.
ii) Mechanistic and structural investigation of the platinum-phosphine-tin(II)halide systems, as well as the palladium-phosphine systems with the aim of improving their catalytic efficiency.
iii) Some examples of the carbonylation (aminocarbonylation, alkoxycarbonylation) of iodo-alkenes, the synthetic analogues of enol triflates, with the aim of the synthesis of compounds of practical importance will also be discussed.
Speaker: L. Kollar
Professor, Department of Inorganic Chemistry, University of Pecs, Hungary
Time: Monday, 12 October 2009, 13:30